منابع مشابه
Metabolic programming: fetal origins of obesity and metabolic syndrome in the adult.
Exposure of the fetus to the intrauterine milieu can have profound effects on the health of the offspring in adulthood. Results of a series of studies demonstrate the powerful influence of the mother's metabolic state on whether the emerging adult develops obesity and hyperinsulinemia. Importantly, these attributes can be passed on to the next generation nongenetically and can be reversed and p...
متن کاملCurrent Thoughts on Maternal Nutrition and Fetal Programming of the Metabolic Syndrome
Chronic diseases such as type 2 diabetes and cardiovascular disease are the leading cause of death and disability worldwide. Although the metabolic syndrome has been defined in various ways, the ultimate importance of recognizing this combination of disorders is that it helps identify individuals at high risk for both type 2 diabetes and cardiovascular disease. Evidence from observational and e...
متن کاملFetal Programming of the Neuroendocrine-Immune System and Metabolic Disease
Adverse uterine environments experienced during fetal development can alter the projected growth pattern of various organs and systems of the body, leaving the offspring at an increased risk of metabolic disease. The thrifty phenotype hypothesis has been demonstrated as an alteration to the growth trajectory to improve the survival and reproductive fitness of the individual. However, when the i...
متن کاملMaternal obesity and fetal metabolic programming: a fertile epigenetic soil.
The incidence of obesity and overweight has reached epidemic levels in the United States and developed countries worldwide. Even more alarming is the increasing prevalence of metabolic diseases in younger children and adolescents. Infants born to obese, overweight, and diabetic mothers (even when normal weight) have increased adiposity and are at increased risk of later metabolic disease. In ad...
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ژورنال
عنوان ژورنال: Annual Review of Physiology
سال: 2012
ISSN: 0066-4278,1545-1585
DOI: 10.1146/annurev-physiol-020911-153245